Arsenal will face holders Barcelona while Chelsea will take on Paris Saint Germain in the round of 16 of the UEFA Champions League.
In the draw held on Monday, Arsenal who lost to Barcelona in the 2006 final, will host the first leg.
On their part, Chelsea will travel to France to be guests of PSG.
The Premier League champions were knocked out of the competition last season by PSG.
In other fixtures, last season's finalists Juventus will square off against Bayern Munich, Roma and Real Madrid will go head-to-head while PSV and Atletico Madrid will do battle.
Others are Benfica up against Zenit, Gent versus Wolfsburg and Dynamo Kyiv facing Manchester City.
The second round kicks off in February.Watch The Premier League Live!! with EXPRESSVPN the #1 Trusted Name in VPN