Liverpool and Manchester United have been drawn against each other in the Europa League round of 16.
The two most successful English clubs were paired in the draw held in Nyon, Switzerland on Friday.
In other heavyweight pairings, Borussia Dortmund will face Tottenham, while La Liga sides Athletic Bilbao and Valencia clash.
The Europa League final will be held in Basel, Switzerland in May.
The full Europa League draw
Shakhtar Donetsk vs Anderlecht
Basel vs Sevilla
Villarreal vs Bayer Leverkusen
Athletic Bilbao vs Valencia
Liverpool vs Manchester United
Sparta Prague vs Lazio
Borussia Dortmund vs Tottenham Hotspur
Fernebahce vs Sporting Braga