Olympiakos, with Brown Ideye in action crashed out of the UEFA Europa League after they were beaten 2-1 at home by Anderlecht.
The win sees Anderlecht progress into the round of 16 with a 3-1 aggregate win.
Konstantinous Fortuounis scored on 29 minutes from the penalty spot to give Olympiakos a 1-0 lead.
After 90 minutes of football failed to yield a goal from either side, the game went into extra-time.
And in extra-time, Frank Acheampong bagged a brace on 103 and 112 minutes, to seal the win for Anderlecht.