Chris Smalling is a doubt for Manchester United’s Premier League encounter against Aston Villa on Saturday due to illness.
The centre-back was substituted shortly before half-time in England’s 1-1 friendly draw against Italy on Tuesday.
And it remains to be seen if Smalling, who drew praise for fine performances in the wins over Tottenham and rivals Liverpool before the international break, will be fit enough to feature in this weekend’s contest at Old Trafford.
“Smallin that fellow Dutchman Robin van Persie is not yet ready to return to action.
The striker has been absent for over a month with an ankle injury and, although he has stepped up his recovery, Saturday’s match will come too soon.
Full-back Luke Shaw is closer to a comeback than Van Persie after pulling out of the England squad with a hamstring problem.
“Van Persie is still injured,” Van Gaal added. “We have a process. He has to go to the final football coach before he comes into my group and he is not there yet. He is still not in my group. But Luke Shaw is in my group.”