Paris Saint-Germain quartet Yohan Cabaye, Marquinhos, Serge Aurier and Lucas Moura all risk missing their Champions League last-16 clash with Chelsea after picking up injuries in Saturday’s draw with Caen.
Cabaye was forced off the pitch after just 16 minutes with a muscular injury and was replaced by Adrien Rabiot.
Marquinhos failed to return for the second half due to a thigh problem, Aurier was stretchered off with another muscle injury, and Lucas also had to be withdrawn in the closing stages.
It meant PSG, having used all of their substitutes, were reduced to nine men in a match they needed to win in order to go top of Ligue 1.
They had led 2-0 thanks to a stunning goal from Zlatan Ibrahimovic and another strike from Ezequiel Lavezzi, but with a two-man disadvantage they crumpled in injury time, conceding twice to draw 2-2.
The setback will come as a huge blow for coach Laurent Blanc ahead of Tuesday’s meeting with Chelsea at the Parc des Princes, with Javier Pastore already doubtful ahead of Saturday’s game.